Saturday, June 13, 2026

Four minutes of daily resistance training can quadruple fitness in older adults

 

 Just four minutes of daily strengthening exercise dramatically increases key factors in quality of life for aging adults, according to a new study led by researchers at Penn State College of Medicine. Results published in PLOS One showed that strength — which impacts fall risk, longevity, independent living and more — significantly improved for adults aged 65 and older in as little as 12 weeks.


Mobility, or physical fitness, is a critical indicator of quality of life for adults ages 65 and above, allowing for completion of daily tasks and movement. Unintentional injuries such as tripping or falling are among the top leading causes of death among adults ages 65 and over, according to the Centers for Disease Control and Prevention. A lack of physical fitness in aging persists because people believe that they can only reap the benefits of exercise with more extensive resistance training workouts — but that’s not the case, according to lead author Christopher Sciamanna, professor of medicine and of public health at Penn State College of Medicine. He said a short four-minute workout is enough to improve upon several factors of critical mobility indicators.

“The human body is designed to improve very quickly,” Sciamanna said. “And just a few repetitions of an exercise performed regularly can lead to huge improvements. Exercise is about forward thinking — think about what you want to be able to do and train for it.”

While resistance training can greatly increase strength in just a few months, less than one in five older adults exercise for the recommended two days per week of muscle-strengthening activity, partially due to routine length, pain and other limitations.

“Exercise is actually really complicated, because you have to decide how many repetitions, how far, how many sets, how much rest and how many times per week,” said co-author Smita Dandekar, associate professor of pediatrics at Penn State College of Medicine. “It's hard work, so there's huge problems with people wanting to do exercise. If we can make it short, we’re part way there.”

Previously, the team had conducted a study called FAST (Functional Activity Strength Training)-1, a smaller scale experiment where 24 older adults performed 30 seconds of push-ups and squats daily, resulting in improved squat performance over six months. Other studies have also shown that a few sets of exercise per week can lead to nearly the same improvements as longer-length routines. Building off of those findings, Sciamanna’s team decided to test the efficacy of a shorter routine.

In the current study, researchers from Penn Statue tested the effects of a program, called FAST-2, to see if it improved mobility and physical capability in adults older than 65. A total of 97 participants with an average age of 74 years old were randomly assigned to receive either the exercise regimen treatment or no intervention. Prior to the study, participants reported performing an average of about 18 minutes of total exercise each week, which is much lower than the recommended amount of at least 150 minutes moderate or 75 minutes vigorous exercise for adults, Sciamanna explained.

The FAST-2 program included four exercises: push-ups, chair stands, two-arm rows and stair stepping. Participants performed each movement for 30 seconds followed by a 30-second rest. Participants received four elastic resistance bands and a stepper with an adjustable height. Written explanations and modifications were provided for the exercises, such as performing pushups with hands on a countertop or wall, or chair stands with hands on the knees.

As participants improved, they were encouraged to progress to higher levels of difficulty, like performing the original version of the exercise if they were doing a modified version or increasing step height on the stepper. To measure participants’ progress, the researchers assessed the participants’ ability and speed at standing up and ability to stand on one leg at the beginning, middle and end of the study.

The tests mimic the movements required in everyday activities, making them useful predictors of potential risks and future need for care, the researchers said.

The authors found that this exercise regimen, which included only 60 seconds of lower body resistance training, was enough to give significant improvements in functional performance: 4.2 more repetitions in a 30 second chair stand, 3.6 more seconds in one-legged stand time and a decrease of 2.3 seconds in sit-to-stand time. These changes point to related improvements in daily life fitness, such as standing up from a chair, climbing stairs and walking, Sciamanna explained.

“These indicators predict your future ability to go into a nursing home, your future likelihood of falling and of developing difficulty walking,” Sciamanna said. “They give you a sense of whether or not you're going to be able to be active in the future.”

One of the additional benefits of a shorter program like FAST-2, Sciamanna explained, is a higher chance that people will stick to the routine. Participants completed the exercise on 81% of days during the study period, demonstrating that the program can fit into days even with time constraints or other concerns that may keep people from continuing an exercise program, even though it could lead to improvements in everyday life.

The findings are a promising indication that resistance training regimens do not have to be long to make a big difference in strength, mobility and quality of life, Sciamanna explained.

“Exercise is the key to freedom,” he said. “Freedom is the ability to be able to do what you want to do, and I would say that if you can't do what you want to do, you're not free. I approach exercise by thinking of what I want to be able to do in 20 years, and then I train to do that.”

Pregnant women may reduce key health risk through less sitting, more light exercise


Women who engage in light physical activity and lessen their sedentary time may significantly reduce the risk of key health problems during pregnancy, according to a new University of Iowa-led study.

Researchers examined the daily behaviors of 470 pregnant women across all stages of pregnancy. Each participant wore a monitor that measured physical activity in 24-hour cycles and another monitor that recorded the time they spent asleep.

Based on observational data collected from the study’s participants, the researchers propose a “Goldilocks Day”-like guide for pregnant women that could reduce by nearly 30% the risk of developing hypertensive disorders of pregnancy (HDP), commonly occurring complications of pregnancy that include chronic hypertension, gestational hypertension, and preeclampsia.

Those recommendations are:

• Reduce sedentary time to fewer than eight hours each day.

• Engage in light physical activity for at least seven hours each day.

• Engage in approximately 22 minutes of moderate to vigorous physical activity, such as a brisk walk, each day.

• Get nearly nine hours of sleep each night.

Sedentary behavior is defined as being mostly inactive, such as sitting or lying down. Light physical activity can include myriad options, such as taking a casual walk, moving around the home, or simply standing. 

“We are identifying the optimal composition of movement behaviors across the day associated with the lowest risk of developing HDP and the most improved health outcomes,” says Kara Whitaker, associate professor in the Department of Health, Sport, and Human Physiology at Iowa and the study’s corresponding author. “This blueprint holds for each and every trimester of pregnancy.”

Study participants were enrolled at study sites in Iowa City, Iowa; Pittsburgh; and Morgantown, West Virginia. The women, 4 in 5 of whom were non-Hispanic white and nearly a quarter of whom were rural residents, wore the activity and sleep monitors for at least a week during each trimester of pregnancy.

The data showed a steep increase in HDP risk for pregnant women who were sedentary for more than 10 hours per day. Conversely, pregnant women who upped their light physical activity to at least four hours per day reduced their HDP risk to 15% from 30%.

“Just moving around more seems to have significant health benefits,” Whitaker says, “and I think it also may be a more feasible target for women who are pregnant who are not exercising regularly.”

The researchers were surprised to find out that participants who engaged in moderate to vigorous physical activity showed no appreciable benefit from longer durations, while sleep beyond a certain duration also yielded no major benefits.

“Through this study, we are providing evidence that reducing sedentary behavior and engaging in light physical activity are important, and maybe more important, when it comes to pregnancy and health,” Whitaker says.

Knowing which mix of behaviors has the greatest impact on women’s health in pregnancy is important, Whitaker notes, because clinical research has shown that women who develop HDP are more than twice as likely to develop heart disease later in life.

“We know that cardiovascular disease is the number one killer of women, and if we can intervene in pregnancy and prevent women from developing a hypertensive disorder of pregnancy, we are putting them on a better trajectory, away from cardiovascular disease and toward more optimal cardiovascular health,” she says.

The study, “Optimal 24-hour movement behaviour compositions across trimesters and risk of hypertensive disorders of pregnancy: the Pregnancy 24/7 cohort study,” was published online June 10 in the British Journal of Sports Medicine.

The findings complement a second study, published online May 27 in the Journal of the American Medical Association, that looked more in depth at the ratio and type of sedentary behavior and light physical activity for the best mix of behaviors to lessen HDP risk. Whitaker is a lead co-author on that study.

Co-authors in the British journal’s study are Alex Crisp, Jaemyung Kim, Karina Smith, Donna Santillan, Mark Santillan, and Bridget Zimmerman, from Iowa; Jacob Gallagher, from Iowa State University; Melissa Jones, from Oakland University in Michigan; Bethany Barone Gibbs, Katrina Wilhite, Alexis Thrower, and Iqra Sheikh, from West Virginia University; and Sabera Rahman, Janet Catov, Christopher Kline, and Maisa Feghali, from the University of Pittsburgh. 

The National Institutes of Health, the University of Iowa Institute for Clinical and Translational Science, the University of Pittsburgh Clinical and Translational Science Institute, and the West Virginia Clinical and Translational Science Institute funded the research.

10.1136/bjsports-2025-111091  

Fasting-mimicking diet reduces gum disease inflammation

 

People who follow a short-term low-calorie diet may have reduced markers of inflammation associated with gum disease.


A new study by King’s College London highlights how lifestyle modifications could be important alongside plaque control in managing gum disease.

While fasting has been linked to reduced inflammation around the body, this is the first to establish a relationship with gum disease too. The findings offer new insights into how oral and wider body health are closely intertwined.

Dr Giuseppe Mainas, first author of the study, King’s College London, said: “Our study suggests lifestyle modifications could be important alongside proper tooth brushing for patients.”

Periodontitis, a serious form of gum disease, affects millions of people worldwide and has been linked to wider health problems, including heart disease and diabetes. While standard treatment focuses on cleaning infected areas around the teeth, researchers are increasingly exploring whether diet can play a role in improving outcomes.

The research included 28 patients from across hospitals in Spain, split into two groups – those who followed a five-day restrictive diet, versus a control group who continued their usual diet.

Patients who fasted ate 1,100 calories for two days, then 750 calories for three days. The sixth day gently introduced more calories with soft foods – then their diets returned to normal by the seventh day. This was repeated three times in six months, with patients reporting the diet easy to stick to.

After six months, samples were analysed from the patients’ blood and gingival crevicular fluid – liquid that comes from the small space between your tooth and gum, which helps gums stay healthy and fight germs.

Those who fasted had reduced markers of inflammation in samples from blood and gum tissue compared to those whose diets stayed the same, including lower levels of C-reactive protein, a general indicator of inflammation around the body. The fasting group also had reduced molecules linked to inflammation specifically in the gums, compared to controls.

Senior-author Prof Luigi Nibali, King’s College London, said: “There may be multiple reasons why fasting is beneficial to gum disease patients. Fasting reduces oxidative stress in the body, a common cause of inflammation, which can damage cells and DNA.

“Intake of high calorific foods and refined carbohydrates, for example in cakes and biscuits, can also cause inflammation – so restricting these foods also reduces oxidative stress in the body.

“It may also be that fasting has beneficial effects on the microbiome – the body’s community of bacteria that help to keep it healthy. However, further research is needed to confirm this relationship.”

Dietary approaches such as fasting-mimicking diets could be investigated in the future as supporting approaches alongside conventional therapies for gum disease, such as professional cleaning and oral hygiene support.

Even low alcohol consumption to cancer, heart disease, and premature death

 

Even what many Americans consider moderate drinking is linked to an increased risk of death, disability, and chronic diseases such as cancer and heart disease, according to a new study published in the Journal of Studies on Alcohol and Drugs.

“This study provides the most comprehensive U.S. estimates to date of lifetime risks of alcohol-attributable mortality and morbidity, showing that even moderate levels of consumption increase the risk of premature death and disability,” said study co-author Katherine M. Keyes, PhD, professor of Epidemiology at Columbia University Mailman School of Public Health. “No protective effect of drinking was observed even at low levels,” noted Keyes, whose research focuses on alcohol use and other substances epidemiology across the life course.

“Even low levels of alcohol use come with health risks,” says lead study author Kevin Shield, PhD, an associate professor at the University of Toronto and a senior scientist who leads the World Health Organization (WHO)/Pan American Health Organization (PAHO) Collaborating Centre in Addiction and Mental Health. “And that risk continues to increase the more someone drinks.”

The researchers, from the United States and Canada, aimed to estimate how lifetime drinking habits affect Americans’ risk of illness and death related to alcohol. After medical experts reviewed more than 7,200 scientific articles on alcohol-related diseases and injuries to determine the level of risk for each condition, the researchers applied those risks to large national health data sets. They then used statistical modeling to estimate how different drinking levels influence long-term health outcomes.

The study offers more concrete guidance than the new U.S. Dietary Guidelines, which currently advise Americans to “limit alcoholic beverages” without specifying how much alcohol is safe to drink. Previous guidelines recommended a daily limit of two alcoholic drinks for men and one for women. The definition of a ‘drink’ varies by beverage type, typically 12 ounces for beer, 5 ounces for wine, and 1.5 ounces for spirits, although that too can vary by alcohol concentration.

While the new U.S. Dietary Guidelines contain a useful ‘less-is-best’ message, they provide no quantitative framework, according to the authors. This study was designed to do just that across the drinking spectrum.

It turns out that two drinks per day, which might be considered ‘moderate’ from a social standpoint, is associated with a substantially elevated risk of a premature death caused by alcohol, they explain.

In addition to mortality risk, researchers examined how drinking patterns influence chronic and acute alcohol-related conditions such as cancer -- including esophageal, oral, and breast -- cardiovascular disease, liver disease, and injury.

The study overturns a common misconception that alcohol can protect health. The researchers did not observe a significant protective effect of alcohol on overall health at any level of consumption. They noted that at low levels, alcohol may be associated with a reduced risk of ischemic heart disease and stroke. But when you look across the full range of health outcomes, including cancer and other chronic diseases, those potential benefits are outweighed by the risks even at 7 drinks per week.

Statistical modeling used in the study to determine health risks was based on “the best possible data,” according to the team. However, they caution one should not assume that means one person’s individual health risk is the same as what is reported here -- that depends on other factors like lifestyle, genetics, drinking patterns, and other choices that differ person to person.

The researchers estimated risk for all health conditions known to be causally related to alcohol and then aggregated these estimates to determine the total health risk. Yet, new research continues to emerge that links alcohol with additional health conditions, such as pancreatic cancer. “Understanding those relationships, and how much alcohol contributes to those risks, is an area that still needs further work,” says Keyes and Shield.

By finding that alcohol consumption is associated with increased risk above one drink per day for both men and women, the study offers a much-needed benchmark.

“Having a clearer threshold helps people better understand what level of drinking is associated with increased risk and make more informed decisions when drinking.”

In an accompanying editorial, Robert M. Vincent, a former associate administrator for the U.S. Substance Abuse and Mental Health Services Administration, discusses his view of the behind-the-scenes environment in which the study was produced. “The Alcohol Intake and Health report was explicitly invited to inform alcohol guidance during development of the Dietary Guidelines for Americans, 2025–2030,” he writes. “Despite the study’s adherence to its mandate, its findings were sidelined.”

Definitive safety data on painkiller use during pregnancy

 

New research from Ben-Gurion University of the Negev (BGU) is offering much-needed clarity to pregnant women worldwide regarding the safety of common painkillers.


A large-scale data analysis of over 264,000 pregnancies led to two studies conducted by BGU’s Dr. Sharon Daniel. The research found that taking paracetamol (Acamol/Tylenol) or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen (Advil/Nurofen) does not increase the risk of birth defects.

 

These findings, published in PLOS Medicine and Human Reproduction Open are based on 20 years of comprehensive clinical data. The research was conducted through the siPREG (Southern Israeli Pregnancy Registry), a high-fidelity data initiative that tracks maternal and fetal health outcomes to answer critical questions for global medicine.

 

This research uses advanced statistical modeling to distinguish between the effect of a drug and the reason it was taken.

“At first glance, raw data might suggest a slight increase in birth defects among women who took these medications,” explained Dr. Daniel, a senior pediatrician at BGU and Director of Innovation at Clalit Health Services. “However, our analysis revealed that the risk was actually tied to the mother’s underlying condition—such as a high fever, infection, or chronic illness—rather than the painkillers themselves.”

Key insights from the siPREG analysis include:

  • NSAIDs are safe in early pregnancy: The research shows no link between first-trimester NSAID use and malformations in any major organ system, including the heart and central nervous system.
  • Paracetamol safety confirmed: One of the most common medications used globally, paracetamol was found to have no independent association with birth defects, stillbirth, or low birth weight.
  • No late-pregnancy complications: Third-trimester use of paracetamol showed no increased risk of newborn renal failure or heart-related complications (premature closure of the ductus arteriosus).

Study 1: NSAIDs During the First Trimester

The first study led by Dr. Daniel comprehensively examined the relationship between NSAID exposure during the first trimester and the risk of birth defects.

Researchers analyzed all pregnancies documented at Soroka University Medical Center between 1998 and 2018 that ended either in birth or pregnancy termination due to suspected fetal abnormalities. In total, 264,858 pregnancies were included, more than 20,000 of which involved NSAID exposure.

The study found no association between NSAID use and birth defects.

Although the raw rate of birth defects was slightly higher among exposed pregnancies (8.2% vs. 7.0%), after adjusting for factors such as fever, inflammatory diseases, pain, maternal background characteristics, and chronic illnesses, the apparent association disappeared. Researchers concluded that the increased risk was mainly explained by the underlying conditions requiring treatment rather than by the medications themselves.

No increased risk was found for specific categories of defects, including in the cardiovascular system, musculoskeletal system, central nervous system, digestive system, and urinary system abnormalities.

Even when each medication was analyzed separately, no increased risk was detected.

“The results showed that NSAID medications are safe to use during the first trimester and are not associated with the development of congenital malformations,” Dr. Daniel stated.

Study 2: Acetaminophen (Paracetamol)

The second study focused on acetaminophen, the most commonly used medication worldwide for pain and fever reduction.

Recent concerns suggested that acetaminophen use during pregnancy might be linked to adverse pregnancy outcomes.

Researchers examined whether use throughout pregnancy was associated with congenital malformations, stillbirth, low birth weight, low Apgar scores, newborn kidney failure, or premature closure of the ductus arteriosus (an important fetal blood vessel).

Acetaminophen exposure occurred in 15.5% of pregnancies during the first trimester, and 14.1% during the third trimester, according to the study.

Again, although the raw rate of birth defects appeared slightly higher among exposed pregnancies (7.9% vs. 6.9%), after statistical adjustment for pregnancy characteristics and medical conditions, researchers found no independent association between acetaminophen exposure and birth defects.

Empowering Mothers and Clinicians

To ensure the findings were robust, the team developed a “sensitivity analysis” to account for the reality of unreported over-the-counter drug use.

“We had to ensure that ‘real-world’ habits didn’t skew our results,” said Dr. Ariel Hassidim, co-author of the research. “We demonstrated that the volume of unreported use would have to be impossibly high.”

By debunking long-standing myths with large-scale evidence, BGU researchers are empowering clinicians to manage maternal pain and fever more effectively. This research follows a similar recent study by the team that confirmed the safety of the antibiotic doxycycline during the first trimester.

“Our goal with the siPREG registry is to replace uncertainty with evidence,” concluded Dr. Daniel. “These findings allow for the responsible, research-based management of pain and fever, ensuring better health outcomes for both mother and child.”

The multidisciplinary research group led by BGU included experts from Soroka University Medical Center, Schneider Children’s Medical Center, and Ariel University.

Danger of taking glucosamine

 

New research has found an association between taking glucosamine, a popular over-the-counter supplement used for joint pain, and a higher likelihood of progressing from mild cognitive impairment to Alzheimer’s disease.


The finding by University of Florida neuroscientists is based on a large retrospective analysis of patients’ records as well as supporting data from advanced imaging technology used to scan human brain specimens and Alzheimer’s disease mouse models.

While the results are preliminary and require validation in a human clinical trial, they provide yet another piece of a much bigger mechanistic picture involving metabolic dysregulation and neurodegeneration, according to the study published today in Nature Metabolism.

“In the United States, there are about 7 million people living with Alzheimer’s and millions more with related dementias such as Lewy body or frontotemporal dementia,” said senior author Ramon Sun, Ph.D., director of the Center for Advanced Spatial Biomolecule Research and associate director for innovation of UF’s McKnight Brain Institute. “A lot of these people actively take an over-the-counter supplement that could be making their disease progression worse.”

As glucosamine is widely available and commonly used by seniors for joint health, researchers set out to investigate whether it could have any effect in Alzheimer’s disease and related dementias, known as ADRD.

With collaborators Yi Guo, Ph.D., and Jiang Bian, Ph.D., the team used artificial intelligence to comb deidentified UF Health records from 2012 to 2024 for patients diagnosed with either ADRD or mild cognitive impairment, or MCI. They found that a significant proportion — 8% — of both types of patients reported taking glucosamine: 1,896 with ADRD and 2,750 with MCI.

After controlling for age, sex and demographics, the analysis showed that glucosamine use was associated with a 25% higher likelihood of progression from mild cognitive impairment to dementia.

In addition, researchers found that taking glucosamine was associated with a 25% increase in mortality risk, or the likelihood of death within a specified time frame, among ADRD patients. For the MCI group, there was no such impact, suggesting the impact of glucosamine may be greater in patients with established dementia.

Notably, said Sun, researchers revealed that a metabolic process in which a protein and sugar-tagging pathway is overactive in Alzheimer’s could be a new target for intervention.

“Our results suggest that altered metabolism is a significant contributor to Alzheimer’s progression and, in addition, addressing the metabolic defect could be an important complement to approaches focused on Alzheimer’s plaques and tangles,” Sun said.

These new insights were made possible by powerful new spatial technology developed by Sun’s lab.

“This technology allows us to examine thousands and thousands of molecules created when the body breaks down food or drugs and to uncover intricate pathways that otherwise would stay hidden,” Sun said.

To peer more deeply into these pathways, the research team focused on glucosamine, a naturally occurring sugar-related molecule that can cross the blood-brain barrier and feed into pathways that build complex sugar structures on proteins. In supplements, it can be made from substances such as shellfish shells or corn.

The findings suggest that glucosamine’s impact may depend on biological context, with the Alzheimer’s brain appearing more vulnerable to this metabolic pathway than the nondiseased brain, said Matt Gentry, Ph.D., chair of UF’s Department of Biochemistry and Molecular Biology and a study co-author.

“The electronic health record data are very provocative,” Gentry said. “While it’s an association and not proof of causality, it does raise an important clinical question that now deserves much more attention.”

In genetically modified mice, the research team showed that glucosamine significantly increased the attachment of sugar residues to proteins in cells. Deficits in “social memory” — or memory of recognition — worsened in glucosamine-treated mice. Conversely, when researchers chemically suppressed this attachment process, memory improved.

Then, in collaboration with Stefan Prokop, M.D., the team found significantly increased sugar attachment in Alzheimer’s brain specimens from the UF Neuromedicine Brain and Tissue Bank compared with normal controls. Taken together, these results suggest that such metabolic dysfunction is not simply a secondary aspect of Alzheimer’s pathology but a contributing driver, they reported.

“Proteins are the cell’s molecular machines, and many of them need sugar tags added in just the right way to fold correctly, travel to the right place and do their jobs,” Gentry said. “What we found in Alzheimer’s is that this sugar-tagging system appears to be overactive. The Alzheimer’s brain is adding too many of these sugar structures, and this seems to contribute to the disease rather than protect against it.”

 

Life after work: Why social connections matter


Social networks may help protect cognitive functioning in later life, particularly among older adults who are no longer working, according to a new IIASA-led study. Drawing on data from 27 European countries, the researchers found that social connections can help compensate for the loss of mentally stimulating interactions linked to work, with different types of relationships benefiting women and men.

As populations age across Europe, maintaining cognitive health has become an increasingly important public health challenge. While previous research has shown that both employment and social relationships are associated with better cognitive functioning, little has been known about how these factors interact or whether their effects differ by gender.

The study was conducted within the framework of the Cognitive Health in Ageing Society (CHIAS) project funded by the Vienna Science and Technology Fund (WWTF). To analyze the relationship between employment status, social connectedness, and cognitive functioning among adults aged 50 and older, the researchers utilized data from the Survey of Health, Ageing and Retirement in Europe (SHARE). The study compared people who were employed, retired, unemployed, or homemakers and assessed how different levels of social network strength related to two measures of cognitive functioning: episodic memory and verbal fluency.

"Our study aims to understand how being employed versus retired, unemployed, or a homemaker, is linked to cognitive functioning in people aged 50 and over in Europe, and, for the first time, to examine whether a strong social network changes that link differently for women and men," explains Thomas Arnhold, a researcher in the IIASA Population and Just Societies Program and lead author of the study.

"A strong social network appears to buffer the cognitive disadvantage of not working, but the pattern is clearly gendered. For women, having a diverse social network appears to compensate for the loss of engagement opportunities often provided by work. For men, close personal ties, often with a spouse or partner, may play a particularly important role. In addition, we found that non-employed men with no social ties had especially low episodic memory scores, highlighting the potential risks associated with social isolation," adds coauthor Daniela Weber, a senior research scholar at IIASA and an assistant professor of health economics at the Vienna University of Economics and Business.

The authors note that the findings have important implications for decision makers developing policies to support healthy ageing across Europe and other countries facing demographic change.

"In ageing societies, helping older adults maintain good cognitive functioning is a major public health priority. Our results suggest that interventions should reflect the different ways men and women benefit from social connections. Programs that help older women build and maintain diverse social networks may be especially valuable, while for older men, preventing social isolation and supporting close relationships may matter more," says Valeria Bordone, Professor of Sociology at the University of Vienna and guest senior research scholar at IIASA.

The study is based on data from more than 145,000 observations collected across 27 European countries between 2011 and 2020, many of which face similar challenges related to population ageing and the growing importance of promoting cognitive health in later life.

The authors conclude that social networks can act as an important source of cognitive stimulation when employment is absent and that gender should be considered a key factor in understanding how social resources contribute to cognitive resilience in older age.

The study, Employment Status and Later Life Cognitive Functioning: A Gendered Perspective on the Moderating Role of the Social Network, is published in the journal Research on Aging.

Reference
Arnhold, T., Weber, D., & Bordone, V. (2026). Employment status and later life cognitive functioning: A gendered perspective on the moderating role of the social network. Research on Aging DOI: 10.1177/01640275261456210