A high sodium diet may increase the risk of eczema

 A high sodium diet may increase the risk of eczema, according to researchers at UC San Francisco (UCSF), who found that eating just one extra gram of sodium per day – the amount in a Big Mac – increases the likelihood of flares by 22%.  

 
Eczema, also known as atopic dermatitis, is a chronic disease that causes dry, itchy skin. It’s one of the most common skin conditions, affecting more than 31 million people in the U.S., and one in 10 people will develop it at some point.  
 
It has become increasingly common in recent years, especially in industrialized countries, implicating environmental and lifestyle factors like diet.  
 
Sodium, which most people consume in the form of salt, increases the risk of hypertension and heart disease. And scientists recently discovered that sodium is stored in the skin, where it may play a role in the inflammation in eczema. 
 
Limiting dietary sodium could be an easy way for eczema patients to manage their disease.  
 
“Most Americans eat too much salt and can safely reduce their intake to recommended levels,” said Katrina Abuabara, MD, associate professor of dermatology at UCSF and corresponding author of the study, which appears June 5, 2024, in JAMA Dermatology.  
 
“Eczema flares can be difficult for patients to cope with,” said Abuabara, who is also associate adjunct professor of epidemiology at the UC Berkeley School of Public Health, “especially when they are unable to anticipate them and don’t have recommendations on what they can do to avoid them.” 
 
For their cross-sectional study, the researchers analyzed data from more than 215,000 people between 30 and 70 years old from the UK Biobank, which includes urine samples and electronic medical records.  
 
They could tell how much sodium each person was eating from urine samples; and they could see whether people had a diagnosis of atopic dermatitis, as well as the severity, from prescription codes.  
 
They found that each additional gram of sodium excreted in urine over 24 hours was associated with 11% higher odds of an eczema diagnosis; 16% higher odds of having an active case; and 11% higher odds of increased severity. 
 
Then, they looked at 13,000 U.S. adults in the National Health and Nutrition Examination Survey and found that eating just one additional gram a day of sodium – about half a teaspoon of table salt – was associated with 22% higher odds that someone would have an active case of eczema.  
 

Father's diet before conception influences children's health

 

Dr. Raffaele Teperino, head of the "Environmental Epigenetics" research group at Helmholtz Munich, along with his research team, has examined the impact of paternal diet on children's health – specifically, the influence of diet before conception. The researchers focused on special small RNA molecules in sperm, known as mitochondrial tRNA fragments (mt-tsRNAs, see background). These RNAs play a key role in the inheritance of health traits by regulating gene expression.

For their study, the researchers used data from the LIFE Child cohort, which includes information from over 3,000 families. The analyses showed that the father's body weight influences the weight of the children and their susceptibility to metabolic diseases. This influence exists independently from other factors such as the mother's weight, the parental genetics, or environmental conditions.

The Father's Diet Influences the Children

To verify the results of their analysis, the research team subsequently conducted experiments with mice. These mice were fed a high-fat diet, meaning food with a higher fat content than a normal diet. This had effects on the reproductive organs of the animals, including the epididymis. The epididymis is the area in the male reproductive system where freshly formed sperm mature. “Our study shows that sperm exposed to a high-fat diet in the mouse epididymis led to offspring with an increased tendency to metabolic diseases,” says Raffaele Teperino.

To deepen the findings, the research team conducted additional studies in the laboratory. They created embryos through in-vitro fertilization (fertilization “in a test tube”). When Teperino's team used sperm from mice that had been exposed to a high-fat diet, they found mt-tsRNAs from these sperm in early embryos, significantly influencing gene expression. This, in turn, affects the development and health of the offspring.

“Our hypothesis that acquired phenotypes over the course of life, such as diabetes and obesity, are transmitted via epigenetic mechanisms across generations, is reinforced by this study. Here, epigenetics serves as a molecular link between the environment and the genome, even across generational boundaries. This occurs not only through the maternal line but, as our research results indicate, also through the paternal line,” explains Prof. Martin Hrabě de Angelis, co-author of this study and Research Director at Helmholtz Munich.

Preventive Health Care for Men Wishing to Become Fathers

The findings from the researchers at Helmholtz Munich underline the role of paternal health before conception – and offer new approaches to preventive health care: “Our results suggest that preventive health care for men wishing to become fathers should receive more attention and that programs should be developed for this purpose, especially with regard to diet,” says Teperino. “This can reduce the risk of diseases like obesity and diabetes in children.”

Background: The Indirect Influence of Fathers

Mitochondria are often referred to as the powerhouses of the cell. They have their own DNA, independent of the DNA in the cell nucleus. This mitochondrial DNA (mt-DNA) produces proteins in the mitochondria via the intermediate mt-RNA and is typically inherited from mothers to offspring. Previously, it was assumed that fathers had no part in the genetic makeup of their offspring's mitochondria. However, recent studies like this one now show that sperm carry fragments of mt-RNA (“mt-tsRNA”) into the egg during fertilization. The mt-tsRNAs play a role in epigenetics, regulating gene expression in the early embryo: they can indirectly influence the development and health of the offspring by modifying the activity of certain genes in the mitochondria. Thus, fathers have an important, albeit indirect, influence on the genetic imprinting of mitochondria and thereby on the energy metabolism of their children.

Experts alert doctors and the public to the arrival of hard-to-treat fungal skin infections in the United States

Healthcare providers should watch out for new and highly contagious forms of ringworm or jock itch, which are emerging as a potential public health threat, according to a pair of reports.

In the first of the studies, experts at NYU Langone Health who focus on the spread of contagious rashes document the first reported U.S. case of a sexually transmitted fungal infection that can take months to clear up even with treatment. In the second report, NYU Langone physicians partnered with authorities at the New York State Department of Health to describe the largest group of patients in the country with a similar fungal strain that resists standard therapies.

Both species of fungi are among a group that causes skin rashes, or tinea, that easily spread on the face and limbs (ringworm), groin (jock itch), and feet (athlete’s foot). However, the tinea explored in the new reports can look very different from the neat, regular circles seen in most forms of ringworm. They may instead be confused for lesions caused by eczema and can therefore go without proper treatment for months.

The first report, publishing online on June 5 in the journal JAMA Dermatology, describes a man in his 30s who developed tinea on his penis, buttocks, and limbs after returning home to New York City from a trip to England, Greece, and California. Genetic tests of fungal samples collected from the patient’s rashes revealed that the infection was caused by the species Trichophyton mentagrophytes type VII (TMVII). This sexually transmitted form of ringworm has been increasingly diagnosed throughout Europe, with 13 instances reported in France in 2023, mostly in men who have sex with men. Notably, the man in the current study said he had sex with multiple male partners during his travels, none of whom reported similar skin issues.

“Healthcare providers should be aware that Trichophyton mentagrophytes type VII is the latest in a group of severe skin infections to have now reached the United States,” said study lead author and dermatologist Avrom Caplan, MD. Caplan is an assistant professor in the Ronald O. Perelman Department of Dermatology at NYU Grossman School of Medicine.

“Since patients are often reluctant to discuss genital problems, physicians need to directly ask about rashes around the groin and buttocks, especially for those who are sexually active, have recently traveled abroad, and report itchy areas elsewhere on the body,” added study senior author John Zampella, MD.

Zampella, an associate professor in the Ronald O. Perelman Department of Dermatology at NYU Grossman says that while infections caused by TMVII are difficult to treat and can take months to clear up, they so far appear to respond to standard antifungal therapies such as terbinafine.

Meanwhile, Caplan says the new skin condition explored in his other new report presents a greater challenge for dermatologists. The study results, published online in May in JAMA Dermatology, center on Trichophyton indotineae (T. indotineae), which is widespread in India and is now reported globally. First confirmed to be in the U.S. last year, the infection causes similar itchy and contagious rashes as TMVII but often resists terbinafine treatment.

To better understand how T. indotineae can evade antifungal drugs, the researchers collected clinical and laboratory data from 11 men and women treated for ringworm in New York City hospitals between May 2022 and May 2023. Their tinea was confirmed to have been caused by T. indotineae. Seven of the patients had received standard doses of terbinafine for anywhere from 14 days (the usual duration for most forms of ringworm) to 42 days, yet their rashes did not improve.

Analyzing the fungal samples’ DNA, the team reported several variations in the genetic code (mutations) that prevent terbinafine from hooking onto fungal cells and poking holes in their protective membranes. According to the study authors, these mutations might help explain why the therapy often failed in some cases to fight the infections.

The results also showed that when seven patients were treated with another antifungal called itraconazole, three recovered entirely and two improved. The problem with this therapy however, Caplan says, is that while effective, the drug can interfere with many medications and can cause nausea, diarrhea, and other side effects that make it hard to use for long periods.

“These findings offer new insight into how some of the fungal skin infections spreading from South Asia can evade our go-to therapies,” said Caplan. “Beyond learning to recognize their misleading signs, physicians will need to ensure their treatment addresses each patient’s quality-of-life needs.”

Caplan adds that he plans to work with leading fungi experts around the U.S. and internationally over the next few months to expand research efforts and track emerging cases.

The researchers caution that while dermatologists should be on the alert for signs of TMVII and T. indotineae in their patients, rates so far remain low in the U.S.

Getting more sleep leads to increased gratitude, resilience and flourishing

 A new study to be presented at the SLEEP 2024 annual meeting found that healthy sleep has a positive impact on gratitude, resilience and flourishing in adults.

Results show that subjective sleepiness and mood disturbances improved with earlier bedtimes that extended sleep by an average of 46 minutes per night and worsened with later bedtimes that reduced nightly sleep by an average of 37 minutes. Measures of flourishing, resilience and gratitude significantly improved across the week with sleep extension and significantly worsened with sleep restriction. Sleep-extended participants also wrote twice as much on their gratitude list as the other participants in the study.

“Polling data indicates that happiness has declined in the U.S. in recent years, and during the same time period, sleep problems have been widespread,” said principal investigator Michael Scullin, who has a doctorate in psychology and is an associate professor of psychology and neuroscience at Baylor University in Waco, Texas. “While it’s recognized that sleep loss worsens mental health symptoms, there have not been experimental studies to test whether increasing sleep improves the positive aspects of life like feelings of purpose, hope and gratitude.”

The study involved 90 adults who were randomly assigned to late bedtimes, early bedtimes or to sleep normally across a single workweek and were monitored by actigraphy. The primary outcomes were changes in state and trait feelings of flourishing, resilience, and gratitude, as well as behavioral expressions of gratitude.

The impacts of poor sleep health are well-documented. The American Academy of Sleep Medicine and Sleep Research Society recommend that adults should sleep seven hours per night on a regular basis to promote optimal health, productivity and daytime alertness.

Scullin noted that experimentally increasing sleep improved these positive attributes, which are at the core of well-being and among the underpinnings of prosocial behaviors.

“Subtly increasing sleep increased people’s gratitude, resilience and feelings of flourishing in life,” Scullin said. 

Adding more beans = greater intake of nutrients and a higher diet quality

Data on nutrient and diet quality outcomes when additional beans are consumed as part of the typical American dietary pattern are scarce. The purpose of this study was to assess the effect of increased bean consumption, in the typical American dietary pattern, on the intake of shortfall nutrients and overall diet quality.

Methods

Using data from the US National Health and Nutrition Examination Survey, 2001–2018, the current analyses modeled the addition of one and two servings of canned and dried beans in all adults (N = 44,574; ≥19 y), younger adults (N = 23,554; 19–50 y) and older adults (N = 21,020; ≥51 y). The beans considered were kidney beans, black beans, chickpeas, and pinto beans.

Results

The modeling of beans to the typical American dietary pattern resulted in significant increases in the intake of several shortfall nutrients, including dietary fiber, potassium, magnesium, iron, folate, and choline (p's < 0.0001). Modeling 1 and 2 servings of beans daily to the US typical dietary pattern significantly increased overall diet quality in all adult age groups considered. Total diet quality, as measured by Healthy Eating Index-2015 scores, was 15–16 % greater with an additional serving of beans and 19–20 % higher with 2 servings of beans relative to the US typical dietary pattern (p values<0.0001).

Conclusions

Dietary patterns that are rich in beans are associated with significantly higher diet quality scores and greater intake of shortfall nutrients, including nutrients of public health concern. Dietary guidance should consider the health benefits associated with the promotion of increased consumption of canned and dry beans in dietary patterns as benefits seen in younger adults continue to older adulthood.

Alcohol-based mouthwash disrupts the balance of your oral microbiome

 

SUMMARY

• Researchers have identified a significant change in composition and abundance of bacteria in study participants’ oral microbiomes after using a popular brand of alcohol-based mouthwash.
• The oral microbiome is the community of bacteria that live in the mouth, they help us digest our food and keep our mouth healthy.
• Researchers found that two species of opportunistic bacteria were significantly more abundant in the mouth after daily use of the alcohol-based mouthwash, Fusobacterium nucleatum and Streptococcus anginosus.
• These two bacteria have been previously linked to several diseases including gum disease and oesophageal and colorectal cancers.
• Although results show potentially damaging alterations to the microbiome, researchers urge that the study results do not mean that the general public should no longer use mouthwash.

The oral microbiome is the community of bacteria that live in the mouth, they help us digest our food and keep our mouth healthy. Changes to the composition of the oral microbiome have been linked to periodontal diseases and some cancers.

New research, published in Journal of Medical Microbiology found that two species of opportunistic bacteria were significantly more abundant in the mouth after three months of daily use of the alcohol-based mouthwash, Fusobacterium nucleatum and Streptococcus anginosus. These two bacteria have been previously linked to gum disease, esophageal and colorectal cancers. Researchers also saw a decrease in a group of bacteria called Actinobacteria which are crucial contributors to the regulation of blood pressure.

Dr Jolein Laumen, first author of the study and researcher at ITM’s Unit of Sexually Transmitted Infections said:

“Alcohol-based mouthwashes are widely available. The public may use them daily to tackle bad breath or prevent periodontitis, but they should be aware of the potential implications. Ideally, long-term usage should be guided by healthcare professionals”.

Vitamin D higher than the recommended daily allowance for children, pregnant people, adults over 75 and adults with prediabetes

 

Healthy adults under the age of 75 are unlikely to benefit from taking more than the daily intake of vitamin D recommended by the Institutes of Medicine (IOM) and do not require testing for vitamin D levels, according to a new Clinical Practice Guideline issued today by the Endocrine Society. For children, pregnant people, adults older than 75 years and adults with high-risk prediabetes, the guideline recommends vitamin D higher than the IOM recommended daily allowance.

Vitamin D use and blood vitamin D levels have been associated with many common diseases. However, whether vitamin D supplementation lowers the risk of these diseases and what vitamin D blood levels are needed for better health have been debated for years.

In this new guideline, the panel of experts established guidelines for vitamin D use and testing for vitamin D levels in healthy persons without established indications for vitamin D treatment or testing. The guideline relied on clinical trials to develop the recommendations.

The guideline, titled “Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline,” was published online and will appear in the August 2024 print issue of The Journal of Clinical Endocrinology & Metabolism (JCEM), a publication of the Endocrine Society.

“The goal of this guideline was to address the vitamin D requirements for disease prevention in a generally healthy population with no underlying conditions that would put them at risk of impaired vitamin D absorption or action,” said Marie Demay, M.D., of Harvard Medical School and Massachusetts General Hospital in Boston, Mass. Demay is the chair of the panel that developed the guideline. “Healthy populations who may benefit from higher dose vitamin D supplements are those 75 and older, pregnant people, adults with prediabetes, and children and adolescents 18 and younger, but we do not recommend routine testing for vitamin D levels in any of these groups.”

Key recommendations from the guideline include:

• We suggest against vitamin D supplements at doses beyond the reference dietary intakes recommended by the IOM in healthy adults under 75 years old.
• We identified the following populations that may benefit from supplementation above the intakes recommended by the IOM because of the potential to reduce specific health risks:
  • Children and adolescents 18 and younger—potential to prevent nutritional rickets and to reduce the chance of respiratory infections.
  • Individuals 75 and older—potential to lower mortality risk.
  • Pregnant people—potential to reduce risk of pre-eclampsia, intra-uterine mortality, preterm birth, small-for-gestational age birth and neonatal mortality.
  • People with prediabetes—potential to reduce progression to diabetes.
• In adults ages 50 years and older who have indications for vitamin D supplementation or treatment, we suggest daily, lower-dose vitamin D instead of non-daily, higher-dose vitamin D.
• We suggest against routine testing for 25-hydroxyvitamin D levels in any of the populations studied, since outcome-specific benefits based on these levels have not been identified. This includes 25-hydroxyvitamin D screening in people with dark complexion or obesity.