Taller individuals are less
likely to develop esophageal cancer and it's precursor, Barrett's esophagus,
according to a new study1 in Clinical
Gastroenterology and Hepatology, the official clinical practice
journal of the American Gastroenterological Association.
"Individuals in the lowest quartile of height (under
5'7" for men and 5'2" for women) were roughly twice as likely as
individuals in the highest quartile of height (taller than 6' for men and
5'5" for women) to have Barrett's esophagus or esophageal cancer,"
said Aaron P. Thrift, PhD, lead study author from the Public Health Sciences
Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
"Interestingly, the relationship between height and esophageal cancer is
opposite from many other cancers — including colorectal, prostate and breast —
where greater height is associated with an increased risk."
Researchers conducted a large pooled analysis using data
from 14 population-based epidemiologic studies within the International
Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), including 1,000
cases of esophageal cancer and twice as many cases of Barrett's esophagus, and
twice as many controls. The researchers conducted multiple analyses, including
using Mendelian randomization (which incorporates genetic information with
traditional approaches) to overcome issues of confounding and bias. The results
from all analyses consistently demonstrated an inverse association between
height and Barrett's esophagus or esophageal cancer. There were no differences
in these estimates based on sex, age, education, smoking, GERD symptoms or body
mass index. Adjusting for abdominal obesity yielded similar results.
"The identification of risk factors, such as height,
will allow us to create more sophisticated and accurate methods to quantify
patient risk, which will hopefully be used in the future to decide who should
undergo endoscopic screening for these conditions," added Dr. Thrift.
The researchers report no obvious explanation for the
association between short height and Barrett's esophagus or esophageal cancer.
Future studies investigating the potential causal mechanisms by which risk for
Barrett's esophagus or esophageal cancer might be influenced by height are
justified.
Esophageal cancer incidence increased eight-fold in the U.S.
from 1973 to 2008. Almost all cases arise from Barrett's esophagus. Learn more
about the management of Barrett's esophagus in the American
Gastroenterological Association medical position statement.
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