What causes us to lose muscle strength as we age and how
exercise can prevent it from happening has never been thoroughly understood,
but McMaster University researchers have discovered a key protein required to
maintain muscle mass and muscle strength during aging.
This important finding means new and existing drugs
targeting the protein may potentially be used to preserve muscle function
during aging.
"We found that the body's fuel gauge, AMP-activated
protein kinase (AMPK), is vital to slow muscle wasting with aging," said
Gregory Steinberg, the study's senior author and professor of medicine at the
Michael G. DeGroote School of Medicine. He is also co-director of MAC-Obesity,
the Metabolism and Childhood Obesity Research Program at McMaster.
"Mice lacking AMPK in their muscle developed much
greater muscle weakness than we would have expected to see in a middle-aged
mouse," said Steinberg. "Instead these mice, which were the
equivalent of being just 50 years old, had muscles like that of an inactive
100-year-old."
The research was published today in Cell Metabolism
and involved members of the MAC-Obesity research team. The lead author is Adam
Bujak, a PhD student of McMaster's Medical Sciences Graduate Program.
"It is known that AMPK activity in muscle is 'dialed
down' with aging in humans, so this may be an important cause of muscle loss
during aging," Steinberg said. Previous research by Steinberg's team has
shown that this "metabolic switch" is turned on with exercise as well
as commonly-used medications including metformin and salicylate (the active
ingredient in Aspirin).
Despite the importance of maintaining muscle function and
strength as we age, there is currently no treatment besides exercise. With an
aging population, age-related muscle wasting and loss of muscle strength is a
growing issue that shortens lives and creates a significant financial burden on
the Canadian health care system.
"We know we can turn on the AMPK pathway with intense
exercise and commonly-used Type 2 diabetes medications," said Steinberg.
"By knowing that AMPK is vital for maintaining muscle mass with aging, we
can now try to adapt exercise regimes and existing drugs to switch on AMPK in
muscle more effectively. The development of new selective activators of the
AMPK pathway in muscle may also be effective to prevent muscle loss with
aging."
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