The study was based on analysis of the UK Biobank, a very
large study comprising 502,664 men and women aged 40-69 years.
Of the total UK Biobank participants, 34,890 individuals
(6.94%) reported taking calcium supplements, 20,004 taking vitamin D
supplements, and 10,406 taking both (2.1%). The researchers found no
associations between the use of calcium supplements and hospital admissions
related to ischaemic heart disease (e.g. heart attacks), any cardiovascular
event, or death following admission for either admission category. Results were
similar for vitamin D and combination supplementation.
Furthemore, regardless of whether participants had a history
of cardiovascular disease or not at baseline, calcium supplementation (with or
without vitamin D) did not increase the risk of future cardiac events, findings
which remained robust after other factors such as age, fatness, medication use
and blood pressure were considered.
Presenting author Prof. Nicholas C. Harvey of the MRC
Lifecourse Epidemiology Unit, University of Southampton, noted, "Calcium
supplementation is widely used, including as an adjunct to therapy for
osteoporosis. Previous studies have provided inconsistent findings with regard
to associations between calcium supplements and cardiovascular events. Our
results, using the largest single study to date, provide reassurance that such
supplementation appears safe."
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