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EVD is contagious and is
transmitted through direct contact with blood, body fluids and tissues
of infected wild animals or people, as well as with surfaces and
materials, such as bedding and clothing, contaminated with these fluids.
Onset of symptoms of EVD can be sudden and can include fever, fatigue,
muscle pain, headache and sore throat. This is followed by vomiting,
diarrhea, rash, impaired kidney and liver function and in some cases
internal and external bleeding. EVD has an incubation period that ranges
from 2 to 21 days. Individuals who provide care for people with EVD,
including health care workers who do not use correct infection control
precautions, are at the highest risk for infection.
Confirmed outbreaks of
EVD have been documented since the 1970s, primarily in areas of
sub-Saharan Africa, where scientists believe the virus is always present
at low levels in certain infected wild animals. On rare occasions,
people become sick with EVD after coming into direct contact with
infected animals, which can then lead to EVD outbreaks when the virus
spreads between people.
An outbreak in three West
African countries (Guinea, Liberia and Sierra Leone) from 2014 to 2016
resulted in more than 28,000 cases of EVD and more than 11,000 deaths
that were caused by Zaire ebolavirus.
The Democratic Republic
of the Congo (DRC) is currently experiencing the world’s second largest
EVD outbreak. In 2018, the World Health Organization (WHO) and the DRC
began to use Ervebo as an investigational vaccine under an expanded
access program to help mitigate this outbreak. With or without
vaccination, it is critical to implement appropriate infection control
and prevention measures as part of efforts to prevent the spread of EVD.
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