Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood

 

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  Vision loss and high cholesterol add to 12 previously identified modifiable risk factors for dementia, concludes a new report from the 2024 Lancet Commission.
• The potential to prevent and better manage dementia is high if action to tackle these risk factors begins in childhood and continues throughout life, even in individuals with high genetic risk for dementia.
• New report outlines 13 recommendations for individuals and governments to help reduce risk, including preventing and treating hearing loss, vision loss, and depression; being cognitively active throughout life; using head protection in contact sports; reducing vascular risk factors (high cholesterol, diabetes, obesity, high blood pressure); improving air quality; and providing supportive community environments to increase social contact.
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Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, even as people around the world live longer and the number of people with dementia is set to rise dramatically in all countries, according to the third Lancet Commission on dementia prevention, intervention, and care, which is being presented at the Alzheimer’s Association International Conference (AAIC 2024)[1].

Based on the latest available evidence, the new report adds two new risk factors that are associated with 9% of all dementia cases —with an estimated 7% of cases attributable to high low-density lipoprotein (LDL) or “bad” cholesterol in midlife from around age 40 years, and 2% of cases attributable to untreated vision loss in later life. 

These new risk factors are in addition to 12 risk factors previously identified by the Lancet Commission in 2020 (lower levels of education, hearing impairment, high blood pressure, smoking, obesity, depression, physical inactivity, diabetes, excessive alcohol consumption, traumatic brain injury [TBI], air pollution and social isolation), which are linked with 40% of all dementia cases [2]. 

The new report estimates that the risk factors associated with the greatest proportion of people developing dementia in the global population are hearing impairment and high LDL cholesterol (7% each), along with less education in early life and social isolation in later life (5% each).

The Commission, authored by 27 world-leading dementia experts, calls for governments and individuals to be ambitious about tackling risks across the life course for dementia, arguing that the earlier we can address and reduce risk factor levels, the better. The report outlines a new set of policy and lifestyle changes to help prevent and better manage dementia. 

More action needed worldwide to reduce dementia risks 

Because of the rapidly ageing population around the world, the number of people living with dementia is expected to almost triple by 2050, rising from 57 million in 2019 to 153 million [3]. Increasing life expectancy is also driving a surge in people with dementia in low-income countries [4]. Global health and social costs related to dementia are estimated at over $1 trillion every year [5].

However, in some high-income countries, including the USA and UK, the proportion of older people with dementia has fallen, particularly among those in socio-economically advantaged areas [6]. The report authors say that this decline in people developing dementia is probably in part due to building cognitive and physical resilience over the life course and less vascular damage as a result of improvements in healthcare and lifestyle changes, demonstrating the importance of implementing prevention approaches as early as possible. 

Nevertheless, most national dementia plans do not make specific recommendations about diversity, equity, or inclusion of people from underserved cultures and ethnicities who are disproportionately affected by dementia risks [7].

“Our new report reveals that there is much more that can and should be done to reduce the risk of dementia. It’s never too early or too late to take action, with opportunities to make an impact at any stage of life”, says lead author Professor Gill Livingston from University College London, UK. “We now have stronger evidence that longer exposure to risk has a greater effect and that risks act more strongly in people who are vulnerable. That’s why it is vital that we redouble preventive efforts towards those who need them most, including those in low- and middle-income countries and socio-economically disadvantaged groups. Governments must reduce risk inequalities by making healthy lifestyles as achievable as possible for everyone.”

To reduce dementia risk throughout life, the Commission outlines 13 recommendations to be adopted by governments and individuals, including (see key messages on page 2 of the report for the full list):

•    Provide all children with good quality education and be cognitively active in midlife. 
•    Make hearing aids available for all those with hearing loss and reduce harmful noise exposure.
•    Detect and treat high LDL cholesterol in midlife from around age 40 years. 
•    Make screening and treatment for vision impairment accessible for all. 
•    Treat depression effectively. 
•    Wear helmets and head protection in contact sports and on bikes. 
•    Prioritise supportive community environments and housing to increase social contact.
•    Reduce exposure to air pollution through strict clean air policies.
•    Expand measures to reduce smoking, such as price control, raising the minimum age of purchase, and smoking bans.
•    Reduce sugar and salt content in food sold in stores and restaurants. 

These actions are especially important given new evidence which shows that reducing the risks of dementia not only increases years of healthy life but also reduces the time people who develop dementia spend in ill health.

As Professor Livingston explains, “Healthy lifestyles that involve regular exercise, not smoking, cognitive activity in midlife (including outside formal education) and avoiding excess alcohol can not only lower dementia risk but may also push back dementia onset. So, if people do develop dementia, they are likely to live less years with it. This has huge quality of life implications for individuals as well as cost-saving benefits for societies.”