The American College of Physicians (ACP) issued new influenza vaccine practice points that say everyone ages 18 to 64 years who are not pregnant or immunocompromised should receive either a standard-dose trivalent or a standard-dose quadrivalent (cell-based, egg-based, MF59-adjuvanted, or recombinant) influenza vaccine for the 2025-2026 influenza season. Those aged 65 years or older who are not immunocompromised should receive either a high-dose trivalent or a high-dose quadrivalent egg-based influenza vaccine. ACP did not examine evidence or make recommendations for pregnant women or immunocompromised adults. The practice points are published in Annals of Internal Medicine.
Influenza A and B drive seasonal epidemics because they are highly infectious, rapidly mutate, and cause a respiratory infection known as the flu. Incidence and severity of influenza vary by year and season but is greatest in the fall and winter. Adults aged ≥ 65 years and adults with comorbidities, such as diabetes, asthma, or chronic obstructive pulmonary disease (COPD), are at greater risk for morbidity and mortality.
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