My New Supplements

 Also see 

1. https://healthnewsreport.blogspot.com/2025/01/recent-research-that-has-changed-ny-diet.html

2. https://healthnewsreport.blogspot.com/2024/05/my-supplements-updated.html

3. https://healthnewsreport.blogspot.com/2025/06/the-latest-addition-to-my-supplements.html

Turmeric Curcumin https://healthnewsreport.blogspot.com/2025/05/green-tea-turmeric-and-berries-may-help.html NAD+ (Nicotinamide Adenine Dinucleotide)  New study shows Alzheimer’s disease can be reversed in animal models to achieve full neurological recovery, not just prevented or slowed Since its discovery, Alzheimer's disease has been considered irreversible. Consequently, research has focused on preventing or slowing the disease, rather than reversing it.  Using different mouse models of Alzheimer’s and analysis of human Alzheimer’s brains, researchers showed that the brain’s failure to maintain normal levels of a central cellular energy molecule, known as NAD+, is a major driver of Alzheimer’s. They showed in animal models not only that preserving normal brain NAD+ balance blocks the onset of Alzheimer’s, but also that restoring brain NAD+ balance in advanced stages of Alzheimer’s enables the brain to reverse pathology and restore normal cognitive function. Therapies that restore brain energy balance could offer a path to recovery from Alzheimer’s. These findings encourage new research into complementary approaches and clinical testing in patients. Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme found in every living cell that plays a critical role in energy production, DNA repair, and cellular maintenance. Its levels naturally decline with age, and this drop is associated with various age-related diseases.  Function and Importance NAD+ exists in two forms: the oxidized form (NAD+) and the reduced form (NADH). It acts as a vital "helper" molecule (cofactor and co-substrate) for numerous enzymes involved in fundamental biological processes.  Energy Production: NAD+ is central to metabolism, carrying electrons from the breakdown of nutrients like glucose and fats to the electron transport chain to generate ATP, the cell's primary energy currency. DNA Repair:  It is a critical substrate for enzymes like poly(ADP-ribose) polymerases (PARPs) which detect and repair DNA damage, helping to maintain genomic stability . Cell Signaling and Regulation: NAD+ regulates key enzymes called sirtuins (often called "guardians of the genome"), which influence gene expression, inflammation, mitochondrial function, and the body's stress responses. Circadian Rhythm: NAD+ levels naturally fluctuate over a 24-hour cycle and help regulate the body's internal clock.  The Role in Aging and Disease NAD+ levels decline with age due to both decreased synthesis and increased consumption by enzymes like CD38 and PARPs which become more active with age-related inflammation and DNA damage. This decline is thought to contribute to conditions such as cognitive impairment, metabolic disorders (like insulin resistance), cardiovascular issues, and loss of muscle function.  Theobromine “Theobromine is associated with slower epigenetic ageing.” TMG (Trimethylglycine) What it is: An amino acid derivative that acts as a methyl donor, helping convert homocysteine to methionine. Benefits: Supports heart health, liver function, muscle performance (creatine production, ATP recycling), and may aid in fat loss by blocking white adipose tissue formation and increasing fat oxidation . Sources: Beets, spinach, wheat bran, or supplements. Considerations: Generally safe, but high doses (4g+) might raise cholesterol; consult a doctor.  EAA  Essential Amino Acids https://healthnewsreport.blogspot.com/2024/10/americans-are-meeting-minimum-needs-for.html Essential Amino Acid (EAA) research shows they are crucial for muscle protein synthesis, recovery, cognitive function, and overall health, with studies highlighting benefits like improved muscle growth with exercise, enhanced cognitive flexibility, and potential for therapeutic use in conditions like low albumin, though specific requirements vary by age and health status, demanding further research into optimal dosages and ratios. Key areas of focus include leucine's role in stimulating muscle synthesis, the impact of EAAs on neurological functions, and understanding needs in aging populations and disease states, moving beyond the simple "essential" label to "functional" amino acids.  Key Research Areas & Findings Muscle Health & Exercise: Free-form EAAs strongly stimulate muscle protein synthesis (MPS), more so than protein isolates, especially when timed around exercise, promoting muscle mass and recovery. Leucine is a key activator of this process, with higher percentages needed for older or less responsive individuals. Cognitive & Psychological Function: Studies show EAAs can improve attention, cognitive flexibility, social interaction, and mood, suggesting roles beyond just physical building blocks. Clinical Applications: EAA supplementation shows promise in managing low albumin levels and improving nitrogen balance in patients with liver or kidney disease, though specific nutrient ratios are vital. Aging & Specific Needs: Research indicates that amino acid requirements, particularly for leucine, may increase with age, with some older adults needing significantly more than young adults, emphasizing the need for age-specific guidelines. Functional Amino Acids: The concept is expanding to recognize that certain EAAs (like leucine and tryptophan) regulate key metabolic pathways, influencing growth, reproduction, and health, making them "functional".