Monday, October 20, 2014

Infection with herpes simplex virus (cold sores) increases the risk of Alzheimer's disease



Alzheimer's disease is the most common among the dementia diseases. In recent years research has increasingly indicated that there is a possible connection between infection with a common herpes virus, herpes simplex virus type 1, and Alzheimer's disease.  A majority of the population carries this virus.  After the first infection the body carries the virus throughout your lifetime, and it can reactivate now and then and cause typical mouth ulcer. The hypothesis which links the herpes virus and Alzheimer's disease is based on that a weakened immune system among the elderly creates opportunities for the virus to spread further to the brain.  There this can in turn start the process which results in Alzheimer's disease.



This link has been confirmed this link in two large epidemiological studies.  In one study, which is based on the Betula project, a study on ageing, memory and dementia, the researchers show that a reactivated herpes infection doubled the risk of developing Alzheimer's disease. This study had 3,432 participants who were followed for 11.3 years on average.  In another study, samples donated to the Medical Biobank at UmeĆ„ University from 360 people with Alzheimer's disease were examined and as many matched people who had not developed dementia.  The samples were taken on average 9.6 years before diagnosis.  This study showed an approximately doubled risk of developing Alzheimer's disease if the person was a carrier of the herpes virus.

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