University of Rochester Medical Center
scientists have discovered new essential information about omega 3 fatty acids
contained in fish oil and how they could be used for asthma patients.
In a paper published in the Journal
of Clinical Investigation--Insight, researchers using cell cultures from
local asthma patients, found that:
• Omega-3 fatty acid products can reduce the production of IgE, the antibodies that cause allergic reactions and asthma symptoms in people with milder cases of asthma;• But in patients with severe asthma who use high doses of oral steroids, the omega-3 fatty acids are less effective because the corticosteroids block the beneficial effects.
Lead author Richard P. Phipps, Ph.D.,
the Wright Family Research Professor of Environmental Medicine, and his lab had
previously shown that certain fatty acids contained in fish oil regulate the
function of immune cells (B cells). They wanted to further investigate the
effects on asthma.
People with asthma have an imbalance
between molecules that dampen inflammation and those that increase
inflammation. Using steroids as treatment controls the inflammation and
relieves symptoms, but does not cure the underlying disease.
Phipps and his team collected blood
from 17 patients at UR Medicine's Mary Parkes Asthma Center and isolated their
B immune cells in the laboratory to explore the impact of pure omega-3-derived
products on IgE and other molecules that fuel the disease. Co-authors Nina Kim,
Ph.D., and Patricia Sime, M.D., the C. Jane and C. Robert Distinguished Chair
in Pulmonary Medicine, conducted much of the laboratory and clinical work, and
compared the results of the 17 patients to donors of healthy blood cells.
Most of the patients who volunteered
for the study were taking corticosteroids in either pill form or by inhaler,
depending upon severity of their asthma. Results showed that all responded to
the omega-3 fatty acids to some degree, as evidenced by a reduction in the
levels of IgE antibodies. But unexpectedly, Phipps said, the cells from a small
subset of patients who were taking oral steroids were less sensitive to the
omega-3 treatment.
Steroids are usually a very effective
treatment for asthma. However, although the science is in the early stages, it
appears that when corticosteroids are used steadily, in some cases the steroids
reduce some of the body's natural ability to fight asthma-related inflammation,
Phipps said.
The URMC discovery coincides with a New
England Journal of Medicine study in late December 2016, showing that
prenatal exposure to fish oil reduced the risk of wheeze and asthma in
children. Phipps noted that the fish oil used as a dietary supplement in the
NEJM study was a special high-quality preparation--and that consumers should
use caution when buying fish oil because not all fish oil is the same.
"You really need high-quality,
standardized material that's been processed and stored correctly before
comparing results from one study to another study," Phipps said. "Our
study used the pure, biologically active products in fish oil, known as
17-HDHA, and we've provided a clear line of evidence for why intake of
high-quality fish oil is good."
Omega 3 polyunsaturated fatty acids
have been shown to have many health benefits. Once ingested, they convert to
special pro-resolving mediators that halt inflammation without also suppressing
the immune system. They can be found in foods such as flax seed oil, salmon,
tuna, anchovies, and walnuts.
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