The review notes that, with age and certain diseases, the robustness of the circadian system decreases and melatonin production is diminished or shifted.
"Deviant circadian rhythms and poor sleep quality are associated with increased risks of cardiovascular, metabolic, and cognitive diseases, as well poor quality of life and increased risks of premature death," said Dr. Nava Zisapel, of Tel Aviv University, in Israel.
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