A
common genetic variant that affects one in three people appears to
significantly increase the risk of colorectal cancer from the consumption of
processed meat, according to study published April 17, 2014 in PLOS Genetics. The study of over
18,000 people from the U.S., Canada, Australia and Europe represents the first
large-scale genome-wide analysis of genetic variants and dietary patterns that
may help explain more of the risk factors for colorectal cancer. Dr Jane
Figueiredo at the Keck School of Medicine of the University of Southern
California, explained that eating processed meat is associated with an
increased risk of colorectal cancer and for about a third of the general
population who carry this genetic variant, the risk of eating processed meat is
even higher compared to those who do not. "Our results, if replicated by
other studies, may provide us with a greater understanding of the biology into
colorectal carcinogenesis," said Dr Ulrike Peters of the Fred Hutchinson
Cancer Research Center's Public Health Sciences Division.
The
study population totaled 9,287 patients with colorectal cancer and a control
group of 9,117 individuals without cancer, all participants in 10 observational
studies that were pooled in the largest meta-analysis sponsored by the National
Institutes of Health-funded Genetics and Epidemiology of Colorectal Cancer
Consortium (GECCO) and Colorectal Cancer Family Registry. Scientists
systematically searched 2.7 million variants to identify those that are
associated with the consumption of meat, fiber, fruits and vegetables. A
significant interaction between the genetic variant rs4143094 and processed
meat consumption was detected. This variant is located on the same chromosome
10 region that includes GATA3, a transcription factor gene previously linked to
several forms of cancer. The transcription factor encoded by this gene plays a
role in the immune system. Dr Figueiredo hypothesized that the genetic locus
found to interact with processed meat may have interesting biological
significance given its location in the genome, but further functional analyses
are required.
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