Wednesday, April 23, 2014

Statins protection widens

In addition to their lipid-lowering effect, statins exert anti-inflammatory and antioxidant effects as well. Statins also provide protection against renal, pulmonary and myocardial ischemia/reperfusion injury. However, little evidence is available on similar changes in cerebral ischemia/reperfusion injury. Researchers have now verified that atorvastatin, a commonly used lipid-lowering drug, protects against cerebral ischemia/reperfusion injury through anti-infammatory and antioxidant effects. The relevant study has been published in the Neural Regeneration Research.

Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than restoration of normal function.

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