The
disruption of a person's circadian rhythm—their 24-hour biological clock—has
been linked to an increased risk of breast cancer, according to new University
of Georgia research. The culprit, in this study in particular, is artificial
light.
"Exposure
to artificial light leads to a significantly higher risk for developing breast
cancer," said Chunla He, a biostatistics graduate student in the UGA
College of Public Health. "To decrease the use of artificial light, people
should avoid working at night and implement earlier bed times."
Her
research, published in the International Archives of Occupational and
Environmental Health, examined key studies that included risk factors for
developing breast cancer.
"A
large body of related research about circadian rhythms and breast cancer
exists," He said. "However, these studies are inconsistent and have a
variety of limitations."
Under
the mentorship of Sara Wagner Robb, assistant professor of epidemiology in the
College of Public Health, He turned to previous studies to see what the
research revealed.
In
addition to other relevant exposures, He examined studies on breast cancer and
flight attendants, who typically work both day and night shifts. The flight
attendants represented a group of workers particularly susceptible to disrupted
circadian rhythms, which are heavily influenced by light.
In
her analysis, He found that employment as a flight attendant was related to an
increased risk of breast cancer.
"People
naturally secrete the hormone melatonin, which helps to regulate the circadian
rhythm," He said. "When the sleep-wake cycle is disrupted by
artificial light, melatonin secretion is adversely affected."
Robb
recommends spreading this information to shift workers so they understand the
harms in disrupting their circadian rhythms.
"Individuals
engaging in this type of work should be aware of these risks and may make
efforts to adjust their circadian rhythms," she said. "Although additional
studies are certainly needed, scientists are becoming increasingly aware of the
health risks associated with night workers and others exposed to
circadian-disrupting behaviors."
Robb
and He also advise that future research needs to examine social
constraints—which may foster disruption of circadian rhythms—on shift workers.
Additionally, shift workers should contact their primary care physicians for
personalized treatment and options.
"This
information tells us the harm in disrupting our natural cycle," He said.
"With this new analysis, we must be cautious in our exposure to artificial
light."
The
article was co-authored by Sonia Taj Anand, a former graduate student in the
College of Public Health; Mark H. Ebell, professor of epidemiology; and John E.
Vena, Medical University of South Carolina.
The
paper, published in the International Archives of Occupational and
Environmental Health, is available online at http://link.springer.com/article/10.1007/s00420-014-0986-x.
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