Absorption of sunscreen active ingredients into bloodstream
The U.S. Food and Drug Administration recommends that
active ingredients in sunscreen absorbed into the bloodstream above a
certain level undergo toxicology testing. Researchers from the FDA
conducted this small randomized clinical trial of 24 healthy volunteers
to determine bloodstream concentrations of four active ingredients
(avobenzone, oxybenzone, octocrylene and ecamsule) in four sunscreens
applied four times per day for four days with blood samples collected
from study participants over seven days.
Researchers report that all
four active ingredients were found in blood samples at levels exceeding
the threshold recommended for toxicology testing. The effect of these
concentrations is unknown and further studies are needed to determine
the clinical significance of these findings. Some limitations of this
clinical trial include that it was conducted under indoor conditions
without exposure to heat, sunlight or humidity, which may affect the
rate of sunscreen absorption, and the study wasn't designed to look at
differences in absorption by the type of sunscreen formulation, skin
type or age of the user. Researchers emphasize that their results don't
suggest people refrain from using sunscreen, which prevents skin damage.
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