Calcium
supplements are widely taken by women for bone health. Previous studies have
suggested that calcium supplements may increase risk of cardiovascular disease,
but the data has been inconsistent. A new study by researchers at Brigham and
Women's Hospital (BWH) did not find that calcium supplement intake increases
risk of cardiovascular disease in women.
The
study is published online May, 2014 in Osteoporosis International.
Researchers
examined supplemental calcium use and incident cardiovascular disease in a
prospective cohort study of 74,245 women in the Nurses' Health Study. The women
did not have cardiovascular disease or cancer at the start of the study. They
were followed for 24 years to document risk of developing heart attack and
stroke. Calcium supplement intake was assessed every four years.
"Our
study has several distinct strengths compared to prior studies including the
large number of participants, long-term follow-up, large number of
cardiovascular events that were confirmed by medical record review, detailed
information about diet and other cardiovascular disease risk factors, and
repeated assessment of calcium supplement use over the 24-year follow up
period," said Julie Paik, MD, MPH, BWH Channing Division of Network
Medicine, Department of Medicine, lead study author.
The
researchers found that at the start of the study, women who took calcium
supplements had higher levels of physical activity, smoked less, and had lower
trans fat intake compared to women who did not take calcium supplements. During
the 24 years of follow-up, there were 2,709 heart attacks and 1,856 strokes.
"Based
on our findings, additional prospective cohort studies examining potential
cardiovascular disease risk associated with calcium supplement use are
needed," said Paik. "Future randomized trials of calcium supplementation,
if conducted, should be designed to optimize assessment of cardiovascular
events."
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