African-American
and European-American men at high risk of prostate cancer have greater odds of
being diagnosed with an aggressive form of the disease if they have a vitamin D
deficiency, according to a new study from Northwestern Medicine® and the
University of Illinois at Chicago (UIC).
Results
of the study were published May 1, 2014 in Clinical Cancer Research, a journal of the
American Association for Cancer Research.
"Vitamin
D deficiency could be a biomarker of advanced prostate tumor progression in
large segments of the general population," said Adam B. Murphy, M.D., lead
author of the study. "More research is needed, but it would be wise for
men to be screened for vitamin D deficiency and treated."
Murphy
is an assistant professor in urology at Northwestern University Feinberg School
of Medicine, a physician at Jesse Brown VA Medical Center and a member of the
Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
"This
is the first study to look at vitamin D deficiency and biopsy outcomes in men
at high risk of prostate cancer," said Rick Kittles, senior author of the
study. "Previous studies focused on vitamin D levels in men either with or
without prostate cancer."
Kittles
is an associate professor in the department of medicine at UIC.
Scientists
examined data collected from a diverse group of more than 600 men from the
Chicago area who had elevated PSA levels or other risk factors for prostate
cancer. Each man was screened for vitamin D deficiency before undergoing a
prostate biopsy.
The
authors were surprised to find that vitamin D deficiency seemed to be a
predictor of aggressive forms of prostate cancer diagnosis in African-American
and European-American men, even after adjusting for potential confounders
including diet, smoking habits, obesity, family history and calcium intake.
"These
men, with severe vitamin D deficiency, had greater odds of advanced grade and
advanced stage of tumors within or outside the prostate," Murphy said.
European-American
men and African-American men had 3.66 times and 4.89 times increased odds of
having aggressive prostate cancer respectively and 2.42 times and 4.22 times
increased odds of having tumor stage T2b or higher, respectively.
African-American
men with severe vitamin D deficiency also had 2.43 times increased odds of
being diagnosed with prostate cancer.
"Vitamin
D deficiency is more common and severe in people with darker skin and it could
be that this deficiency is a contributor to prostate cancer progression among
African-Americans," Murphy said. "Our findings imply that vitamin D
deficiency is a bigger contributor to African-American prostate cancer."
Unless
it is severe, vitamin D deficiency is fairly asymptomatic, so more effort needs
to be put on screening, Murphy said.
"It is a good idea to get your
levels checked on a yearly basis," Murphy said. "If you are
deficient, you and you doctor can make a plan on how to reverse it through
diet, supplements or other therapies."
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